uPA Receptor/U-PAR Rabbit pAb
Cat No.: APA1529
Size：
| Product Name: | uPA Receptor/U-PAR Rabbit pAb |
| Cat No.: | APA1529 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | ICC/IF,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | ICC/IF: 1:20 FC: 1:50 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human uPA Receptor/U-PAR |
| calculated molecular weight: | 37 kDa |
| observed molecular weight: | |
| genbank accession number: | Q03405 |
| gene id (ncbi): | 5329 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CD87; UPAR; URKR; U-PAR |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |