Flt3/CD135 Rabbit pAb
Cat No.: APA1517
Size：
| Product Name: | Flt3/CD135 Rabbit pAb |
| Cat No.: | APA1517 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | FC |
| clonality: | Polyclonal |
| recommended dilution: | FC: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Flt3/CD135 |
| calculated molecular weight: | 113 kDa |
| observed molecular weight: | |
| genbank accession number: | P36888 |
| gene id (ncbi): | 2322 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | FLK2; STK1; CD135; FLK-2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] |