Slow Skeletal Myosin Heavy chain Rabbit pAb
Cat No.: APA1477
Size：
| Product Name: | Slow Skeletal Myosin Heavy chain Rabbit pAb |
| Cat No.: | APA1477 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | IHC |
| clonality: | Polyclonal |
| recommended dilution: | IHC: 1:200 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Slow Skeletal Myosin Heavy chain |
| calculated molecular weight: | 224 kDa |
| observed molecular weight: | |
| genbank accession number: | P12883 |
| gene id (ncbi): | 4625 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CMH1; MPD1; SPMD; SPMM; CMD1S; MYHCB |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008] |