Collagen IV Rabbit pAb
Cat No.: APA1444
Size：
| Product Name: | Collagen IV Rabbit pAb |
| Cat No.: | APA1444 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | IHC |
| clonality: | Polyclonal |
| recommended dilution: | IHC: 1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Collagen IV |
| calculated molecular weight: | 161 kDa |
| observed molecular weight: | |
| genbank accession number: | P02462 |
| gene id (ncbi): | 1282 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | BSVD; BSVD1; RATOR; PADMAL; COL4A1s |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |