Haptoglobin Rabbit pAb
Cat No.: APA1436
Size：
| Product Name: | Haptoglobin Rabbit pAb |
| Cat No.: | APA1436 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:500 FC: 1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Haptoglobin |
| calculated molecular weight: | 39 kDa |
| observed molecular weight: | 39 kDa |
| genbank accession number: | P00738 |
| gene id (ncbi): | 3240 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | BP; HPA1S; HP2ALPHA2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn--s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson--s disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |