Pepsinogen II/PGC Rabbit pAb
Cat No.: APA1429
Size：
| Product Name: | Pepsinogen II/PGC Rabbit pAb |
| Cat No.: | APA1429 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:500 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Pepsinogen II/PGC |
| calculated molecular weight: | 42 kDa |
| observed molecular weight: | 42 kDa |
| genbank accession number: | P20142 |
| gene id (ncbi): | 5225 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | PEPC; PGII |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] |