FITC Anti-Mouse Foxp3 Antibody[3G3]
Cat No.: FCE3630
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| Product Name: | FITC Anti-Mouse Foxp3 Antibody[3G3] |
| Cat No.: | FCE3630 |
| host: | Mouse |
| uniprot id: | Q99JB6 |
| geneid: | 50943,20371,317382 |
| application: | ICFCM |
| isotype: | Mouse IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | Foxp3 |
| conjugation: | FITC |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| clone no.: | 3G3 |
| background: | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25-?cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in --scurfy-- mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. |
| target synonym: | Forkhead box protein P3;IPEX;JM2;Foxp3; |
| concentration: | 5 μL/Test |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | C57BL/6 splenocytes are surface stained with APC Anti-Mouse CD4 Monoclonal Antibody followed by fixation and permeabilization using the Foxp3 Staining/Transcription Factor Buffer Set and intracellular staining with FITC Anti-Mouse Foxp3 Monoclonal Antibody. |